Rubella virus infection in a healthy individual typically presents few problems. On the other hand, infection of pregnant women during the first trimester often leads to serious sequelae in the infant. Serological procedures can be very useful in ruling out a particular diagnosis. The absence of antibody to a given infectious agent can exclude that agent from consideration as a cause of the illness while a positive finding indicates past or present infection. A variety of methods have been employed for the detection of antibodies including indirect immunofluorescence, complement fixation, passive hemagglutination, neutralization and enzyme-linked immunosorbent assays (ELISA). These procedures each require a serum sample and, in many cases, equipment such as a fluorescent microscope or spectrophotometer is necessary.

ImmunoDOT TORCH test also includes a Rubella IgG dot as indicated in TORCH IgG testing. This analyte is included as part of a comprehensive prenatal screening protocol. ImmunoDOT TORCH test offers a simple simultaneous determination of the antibody status for the most common TORCH analytes.